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GPCR Compound Profiling
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Our compound profiling service reduces time and cost of GPCR drug discovery.
If you have a panel of lead candidates and need to concentrate on SAR optimization, Multispan can help you make the right decision.
You will have a choice of testing your compounds in either our fast growing collection of
stable cell lines or transiently
transfected assay panel validated with second messenger measurement, such as Calcium, with
FLIPR Calcium 4 Assay Kit.
Our collection of cell-based assays represents a wide range of GPCR targets to survey the specificity of drug candidates
with direct functional readouts.
Features & Benefits
- Corporate commitment: Stable, growing, and long-term corporate emphasis on compound profiling service.
- Flexibility in assay format: not attached to only one functional readout. Customer shall have access to Calcium, cAMP, and other functional assay platforms.
- Robust Proprietary Technology: Enabling expression and assay development of “difficult” and important GPCR targets, such as FFA, Prostanoid, LPA, S1P and mGluR families.
- Functional data: Higher value result. Captures allosteric compounds which do not affect native ligand binding but alter downstream signaling.
- Flexibility in panel size: Customer can pick from 140 validated assays. 320 cDNAs are cloned for new custom panel.
- Proven track record: Consistent customer care and high customer returning rate.
- Quick turnaround: 2 weeks from receiving compounds to delivering dataset. Quick upfront new assay set-up.
All intellectual property resulted from screening is retained by the client.
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