MULTISCREEN™ HTS-Ready Ortholog GPCR Panel

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Incorporation of ortholog screens early in hit series evaluation can provide valuable insights for lead optimization

• Discover compounds’ cross-species activity variation early

• Reduce animal model translational uncertainty

• Mouse, rat, dog, rhesus, cynomolgus, rabbit, ferret, guinea pig, etc

• HTS-ready assay conditions from “ALL Assays in One”

MULTISCREEN™ stable cell lines

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EXAMPLE: MULTISCREEN™ Ortholog cAMP Assays

Rat IP1 Receptor

Rat DP1 Receptor

HTS to Lead Compound

Emphasizing Ortholog Testing in Real-Time

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MULTISCREEN™ Ortholog GPCRs

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Custom assay panels for your specific needs are available! Inquire: info@multispaninc.com

What do our customers say?

"Multispan provided us with target engagement data for a novel target for a rare genetic neurological disease. I collaborated with scientists at Multispan to optimize the conditions for a Gi/o coupled GPCR to generate robust assay data for both AI-generated focused library screening and dose-response potency data. In conjunction with our in-house brain organoid disease model data, we successfully identified candidates for lead optimization that engage the target and rescue the disease phenotype. Multispan scientists were proactive to suggest approaches to optimize assay quality and conducted additional experiments on several occasions to ensure high assay quality."

- Jon Hawkinson, Ph.D.

Former Vice President, Drug Discovery, Vyant Bio Adjunct Professor, Department of Medicinal Chemistry, University of Minnesota

info@multispaninc.com

www.multispaninc.com