Assay Native GPCRs in HTS with MULTISCREEN™ β-Arrestin Sensor

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Don't Let GPCR Tagging Bias Your Results!

• Study GPCRs in native form in ONE single cell line for all signaling pathways:

receptor activation, trafficking, and signaling bias

• Easily capture real-time signaling kinetics

• No-wash homogeneous assay in 96- or 384-well microplates

• Available as assay kits and custom cell lines

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MULTISCREEN™ GPCR β-Arrestin Assay Examples:

HEK293T AT1 Stable Cell Line Transiently Infected

with β-Arrestin1 and β-Arrestin2 BacMam Sensors

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Screen Orphan GPCRs at Multispan to Save 6-12 Months of Assay Development and Transfer

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What do our customers say?

“Over the past two years I worked with Multispan on the discovery and optimization of partial agonist ligands for a Gi/o coupled GPCR. Multispan supported the in vitro effort that enabled the compound optimization by implementing and running radiolabel binding assays to evaluate the affinity of ligands, cAMP assays in agonist and antagonist modes to evaluate functional activity, GTPgS assays to accurately measure the efficacy of ligands on the receptor, ARRB-2 assays to evaluate the arresting signaling pathway and receptor internalization assays to evaluate functional activity. The work performed by Multispan was professional with good reproducibility from week-to-week, quick turnaround and cost effective. The Multispan team is easy to work with and when the assays deviated from the norm they were quick to repeat the data and address problems."

Julio Medina, Ph.D.

R2M Pharma Inc.

C.E.O.

info@multispaninc.com

www.multispaninc.com