MULTISCREEN™ GTPγS assay for robust GPCR drug discovery HTS

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We help discover your IND-enabling candidate with confidence!

Uniquely elegant GTPγS assay format

Ensured by

1. 500+ functionally-validated GPCR stable cell lines for

VERSATILITY

2. Stable cell-line derived membrane preparation for

HIGH QUALITY

3. Rigorous assay protocols and processes for

ROBUSTNESS AND REPRODUCIBILITY

4. An experienced team for

CUSTOMIZATION

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Optimized to meet any HTS and lead optimization needs

MULTISCREEN™ GPR91 GTPγS Assay Example

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GTPγS binding, a GPCR proximal event after ligand binding before downstream cAMP, Ca^++, and β-Arrestin signaling

What do our customers say?

“Over the past two years I worked with Multispan on the discovery and optimization of partial agonist ligands for a Gi/o coupled GPCR. Multispan supported the in vitro effort that enabled the compound optimization by implementing and running radiolabel binding assays to evaluate the affinity of ligands, cAMP assays in agonist and antagonist modes to evaluate functional activity, GTPgS assays to accurately measure the efficacy of ligands on the receptor, ARRB-2 assays to evaluate the arresting signaling pathway and receptor internalization assays to evaluate functional activity. The work performed by Multispan was professional with good reproducibility from week-to-week, quick turnaround and cost effective. The Multispan team is easy to work with and when the assays deviated from the norm they were quick to repeat the data and address problems."

Julio Medina, Ph.D.

R2M Pharma Inc.

C.E.O.

info@multispaninc.com

www.multispaninc.com