Speed and Quality to Fast-Track Target to IND

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Eblast 1 February 2023 Title-1

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We helped bring many candidates into the clinic and the market

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Assay Expertise - Develop the Right Assay

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We don’t just run assays, we build assays!
Jumpstart HTS with >1500 MULTISCREEN™ stable cell lines, membranes, and assays
Full/partial/inverse agonist, antagonist, PAM, NAM modes

Publication Quality - Make the Right Decision

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Control IC50/EC50 variance < 3-fold; CV% < 10%
Tracked in each plate to ensure consistency
100% transparency in data sharing

Integrity is our centerpiece!

Rapid Turnaround - Shorten Decision Cycles

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Weekly SAR primary assays: 1 day!
Monthly SAR secondary assays: 5 days
HTS of 100K compound library: 1-month
32-GPCR off-target functional assay panel: 10 days

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Data Example

(Positive control data over 10 weeks)

MULTISCREEN™ Human GLP-1 Receptor cAMP Assay

GLP-1 SAR

Assay Examples

β-arrestin • GTPγS • Radioligand binding • Internalization
Ca⁺⁺ • cAMP • pERK • pNFκB • pGRK-2 • Reporter • IP-1 • DNA-PK • AMPK
Chemotaxis • Insulin secretion • Cytokine

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